Faculty
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Lee, Yun Kyung, Ph.D.Professor
Gut microbiota, Intestinal stem cell, Gut organoid, Mucosal immune system
Room 405, SIMS
+82-41-413-5031
yunklee@sch.ac.kr
We encounter the tremendously diverse microbial communities over the course of our lives starting with a birth. The recent understanding from numerous studies indicates that our health is highly dependent on the contribution of intestinal commensal bacteria, called microbiota. To thrive within our body, the microbiota has evolved to play an irreplaceable role in the host health. Our immune system has been also evolutionally developed the sophisticated mechanisms to distinguish between commensal microbes and pathogens to maintain the symbiosis. The intestinal tract of small intestine and colon is a complex ecosystem of microbiota, enriched nutrients, and host cells. Considering this, we need to learn how the interaction between microbiota and host immune system in gut ecosystem is regulated.
Our laboratory is basically interested in how the microbiota plays a role in regulating host immune system to prevent and/or treat the numerous immunological disorders.
Currently, we are studying the following subjects.
1. The application of gut microbiota in the treatment of intestinal inflammation
2. The role of Intestinal barriers (gut organoid, intestinal stem cells, intestinal epithelial cells) in mucosal immune system
3. Gut microbiota in immune-related diseases
4. The study of gut microbiota and immune cells in different diet conditions
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Principal Investigator
Yun Kyung Lee, Ph.D. Professor Gut microbiota, Intestinal stem cell, Gut organoid, Mucosal immune system Office: Room 405, SIMS Phone: +82-41-413-5031 E-mail: yunklee@sch.ac.kr Post-Doctoral Scholar. California Institute of Technology Ph.D. University of Alabama at Birmingham M.S. Pohang University of Science and Technology B.S. Chonnam National University Postdoctoral Researcher Panida Sittipo, Ph.D. Ph.D. SIMS, Soonchunhyang University M.S. Chulabhorn Graduate Institute, Thailand B.S. Kasetsart University, Thailand Graduate Students Marina Putri Pranata B.S. Atma Jaya Catholic University of Indonesia |
Sittipo P, Pham HQ, Park CE, Kang G, Yong Z, Ji HJ, Jang A, Seo HS, Shin J, Lee YK* Irradiation-induced intestinal damage is recovered by the indigenous gut bacteria Lactobacillus acidophilus. Frontiers in Cellular and Infection Microbiology (2020 Aug 18) 10:415
Sittipo P, Shim JW, Lee YK* Microbial metabolites determine host health and the status of some diseases. International Journal of Molecular Sciences (2019 Oct 24) 20(21);5296
Lobionda S, Sittipo P, Kwon HY, Lee YK* The role of the gut microbiota in intestinal inflammation with respect to diet and extrinsic stressors. Microorganisms (2019 Aug 19) 7(8):271
Lee YK*, Mehrabian P, Boyajian S, Wu WL, Selicha J, Vonderfecht S, Mazmanian SK The protective role of Bacteroides fragilis in a murine model of colitis-associated colorectal cancer mSphere (2018 Nov 14) 3(6)
Sittipo P, Lobionda S, Choi K, Sari IN, Kwon HY,ﾠLee YK* Toll-like receptor 2-mediated suppression of colorectal cancer pathogenesis by polysaccharide A fromﾠBacteroides fragilis. Frontiers in Microbiology (2018 Jul 17) 9:1588
Sittipo P, Lobionda S, Lee YK*, Maynard CL. Intestinal microbiota and the immune system in metabolic diseases. Journal of Microbiology (2018 Mar) 56(3): 154-162
Lee YK*, Landuyt AE, Lobionda S, Sittipo P, Zhao Q, Maynard CL. TCR-independent functions of Th17 cells mediated by the synergistic actions of cytokines of the IL-12 and IL-1 families. PLoS One (2017 Oct 12) 12(10): 1-17
Cekanaviciute E, Yoo BB, Runia TF, Debelius JW, Singh S, Nelson CA, Kanner R, Bencosme Y,ﾠLee YK, Hauser SL, Crabtree-Hartman E, Katz Sand I, Gacias M, Zhu Y, Casaccia P, Cree BAC, Knight R,ﾠMazmanian SK, Baranzini SE. Gut bacteria from multiple sclerosis patients modulate human T cells and exacerbate symptoms in mouse models. Proc. Natl. Acad. Sci. USA (2017 Oct 3) 114 (40): 10713-10718 [PMID: 28893978]
Wang Y, Godec J, Ben-Aissa K, Cui K, Zhao K, Pucsek AB, Lee YK, Weaver CT, Yagi R, Lazarevic V. The tranion factors T-bet and Runx are required for the ontogeny of pathogenic interferon-γ-producing T helper 17 cells. Immunity (2014 Mar 20) 40(3):355-66.
Zindl CL, Lai JF, Lee YK, Maynard CL, Harbour SN, Ouyang W, Chaplin DD, Weaver CT. IL-22-producing neutrophils contribute to antimicrobial defense and restitution of colonic epithelial integrity during colitis. Proc. Natl. Acad. Sci. USA (2013 Jul 30) 110(31):12768-73
Lee YK, Menezes JS, Umesaki Y, Mazmanian SK Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis. Proc. Natl. Acad. Sci. USA (2011 Mar 15) 108 Suppl 1:4615-22.
Palmer MT, Lee YK, Maynard CL, Oliver JR, Bikle DD, Jetten AM, Weaver CT Lineage-specific effects of 1,25-dihydroxyvitamin D(3) on the development of effector CD4 T cells. J. Biol. Chem. (2011 Jan 14) 286(2): 997-1004.
Lee YK, Mazmanian SK Has the microbiota played a critical role in the evolution of the adaptive immune system? Science (2010 Dec 24) 330(6012): 1768-73
Mukasa R, Balasubramani A, Lee YK, Whitley SK, Weaver BT, Shibata Y, Crawford GE, Hatton RD, Weaver CT. Epigenetic instability of cytokine and tranion factor gene loci underlies plasticity of the T helper 17 cell lineage. Immunity (2010 May 28) 32(5): 616-27.
Lee YK, Mukasa R, Hatton RD, Weaver CT. Developmental Plasticity of Th17 and Treg cells. Current Opinion in Immunology (2009 Jun) 21:1-7.
Lee YK, Turner H, Maynard CL, Oliver JR, Chen D, Elson CO, Weaver CT. Late developmental plasticity in the T helper 17 lineage. Immunity (2009 Jan 16)30(1): 92-107.
