□ Introduction

‧ Securing research capabilities at an international level by transferring the world’s best research know-how related to metabolic diseases to a local research cluster in the Chungnam area

‧ Improving core research competencies in the Chungnam area through the formation and establishment of an international cooperative research cluster in Chungnam

‧ Establishing a regional innovation research center with core technology for the metabolic disease industry, and cultivating international research manpower in the area of metabolic diseases.

‧ Securing original technology for β-cell tissue regeneration

‧ Establishing a screening platform based on new β-cell organ-on-a-chip.

‧ Developing innovative treatments for metabolic diseases for an aging society

‧ Creating a future medical infrastructure and cultivating professional manpower in the Chungnam region.

□ Central goal

○ Vision: A leading regional innovation research center driving sustainable and self-sustaining innovative growth in the Chungcheong area.

○ Objective: Research on new diabetes treatment through the interaction of adipose tissue and beta cells.

 □ Final research objective

For type 2 diabetes as well, transplantation of β-cells or regeneration of β-cells through stem cell therapy is considered a useful diabetes treatment. Regarding insulin resistance, we propose a new paradigm in which the expansion of β-cells occurs through differentiation, proliferation, and regeneration by mediators of the inflammatory response secreted from abdominal fat.

□ Research contents by stage and by group