A UBE2O-AMPKα2 Axis that Promotes Tumor Initiation and Progression Offers Opportunities for Therapy.
Song SJ. et al., Cancer Cell. 2017 Jan
UBE2O is localized in the 17q25 locus, which is known to be amplified in human cancers, but its role in tumorigenesis re
Research Highlight
Effective Delivery of Antigen-Encapsulin Nanoparticle Fusions to Dendritic Cells Leads to Antigen-Specific Cyt
Ryu S. et al., ACS Nano. 2016 Aug
In cancer immunotherapy, robust and efficient activation of cytotoxic CD8(+) T cell immune responses is a promising, but challenging task. Dendritic cells
Research Highlight
Physiological/pathological ramifications of transcription factors in the unfolded protein response
Han J. et al., Genes & Development, 2017 July
Numerous environmental, physiological, and pathological insults disrupt protein-folding homeostasis in the endoplasmic r
Research Highlight
Parkin and PINK1 Patient iPSC-Derived Midbrain Dopamine Neurons Exhibit Mitochondrial Dysfunction and α-Synucl
Shim JW. et al., Stem Cell Reports. 2016 Oct
Parkinson's disease (PD) is characterized by the selective loss of dopamine neurons in the substantia nigra; however, the mechanism of neurodegeneration in PD remains unclear. A subset of familial PD is linked to mutatio
Research Highlight
MiR-31/SDHA Axis Regulates Reprogramming Efficiency through Mitochondrial Metabolism
Lee MR et al., Stem Cell Reports. 2016 July
Metabolism is remodeled when somatic cells are reprogrammed into induced pluripotent stem cells (iPSCs), but the majority of iPSCs are not fully reprogrammed. In a shift essential for reprogramming,
