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  • Research Highlight

    A UBE2O-AMPKα2 Axis that Promotes Tumor Initiation and Progression Offers Opportunities for Therapy.
    Song SJ. et al., Cancer Cell. 2017 Jan
    UBE2O is localized in the 17q25 locus, which is known to be amplified in human cancers, but its role in tumorigenesis re
  • Research Highlight

    Effective Delivery of Antigen-Encapsulin Nanoparticle Fusions to Dendritic Cells Leads to Antigen-Specific Cyt
    Ryu S. et al., ACS Nano. 2016 Aug
    In cancer immunotherapy, robust and efficient activation of cytotoxic CD8(+) T cell immune responses is a promising, but challenging task. Dendritic cells
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    Physiological/pathological ramifications of transcription factors in the unfolded protein response
    Han J. et al., Genes & Development, 2017 July
    Numerous environmental, physiological, and pathological insults disrupt protein-folding homeostasis in the endoplasmic r
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    Parkin and PINK1 Patient iPSC-Derived Midbrain Dopamine Neurons Exhibit Mitochondrial Dysfunction and α-Synucl
    Shim JW. et al., Stem Cell Reports. 2016 Oct
    Parkinson's disease (PD) is characterized by the selective loss of dopamine neurons in the substantia nigra; however, the mechanism of neurodegeneration in PD remains unclear. A subset of familial PD is linked to mutatio
  • Research Highlight

    MiR-31/SDHA Axis Regulates Reprogramming Efficiency through Mitochondrial Metabolism
    Lee MR et al., Stem Cell Reports. 2016 July
    Metabolism is remodeled when somatic cells are reprogrammed into induced pluripotent stem cells (iPSCs), but the majority of iPSCs are not fully reprogrammed. In a shift essential for reprogramming,
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