Faculty
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Moon, Jong-seok, Ph.D
Associate Professor
Immunometabolism, Metabolic cell death, Human metabolic diseases
Room 307, SIMS
+82-41-413-5022
jongseok81@sch.ac.kr
INFLAMMASOME & NECROSOME LAB
● NLRP3 INFLAMMASOME RESEARCH
We still have only a very limited understanding of Chronic Inflammation on Metabolic diseases. Answering questions about this is essential for understanding the mechanistic role it plays on NLRP3 inflammasome activation by Diabetes-driven Metabolites and DAMPs (Damage Associated Molecular Patterns). We are developing molecular target and Specific inhibitors of NLRP3 inflammasome activation in macrophages.
Fig.1 NLRP3 inflammasome in macrophages
● NECROSOME RESEARCH
In an effort to gain a better understanding of Necroptosis (Programmed Necrosis), We have investigate the function and molecular mechanism of Necroptotic cell death on Human metabolic diseases. We are working on the development of Diagnostic marker for Metabolic cell death by Necroptosis.
Fig.2 Necroptosis (Programmed Necrosis)
● TYPE 2 DIABETES & ALZHEIMER'S DISEASES RESEARCH
1. The regulation of NLRP3 inflammasome in human metabolic diseases
2. The regulation of Necroptosis in human metabolic diseases
3. The activation of Metabolic inflammation in human diseases
4. The activation of Metabolic cell death in human diseases
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Principal Investigator
JONG-SEOK MOON, Ph.D. Biography B.S. in Life science, Hanyang University, Korea M.S. in Cell biology and Pharmacology, Yonsei University, Korea Ph.D. in Cell biology and Pharmacology, Yonsei University, Korea Postdoctoral fellow, Harvard Medical School, U.S.A Postdoctoral fellow, Weill Cornell Medical College, U.S.A Instructor, Weill Cornell Medical College, U.S.A Assistant Professor, Soonchunhyang Institute of Medi-bio Science (SIMS), Soonchunhyang University, Korea Associate Professor, Soonchunhyang Institute of Medi-bio Science (SIMS), Soonchunhyang University, Korea Research Interest The regulation of metabolic inflammation and metabolic cell death in human diseases 1. The regulation of NLRP3 inflammasome in human metabolic diseases 2. The regulation of Necroptosis in human metabolic diseases 3. The activation of Metabolic inflammation in human diseases 4. The activation of Metabolic cell death in human diseases mechanisms |
1. Elevated CLOCK and BMAL1 Contribute to the Impairment of Aerobic Glycolysis from Astrocytes in Alzheimer's Disease. Yoo ID, Park MW, Cha HW, Yoon S, Boonpraman N, Yi SS, Moon JS*. Int J Mol Sci. 2020 Oct 23;21(21):7862. doi: 10.3390/ijms21217862.
2. NOX4 Deficiency Exacerbates the Impairment of Cystatin C-Dependent Hippocampal Neurogenesis by a Chronic High Fat Diet. Jiranugrom P, Yoo ID, Park MW, Ryu JH, Moon JS*, Yi SS. Genes (Basel). 2020 May 19;11(5):567. doi: 10.3390/genes11050567.
3. GLUT1-dependent glycolysis regulates exacerbation of fibrosis via AIM2 inflammasome activation. Cho SJ, Moon JS, Nikahira K, Yun HS, Harris R, Hong KS, Huang H, Choi AMK, Stout-Delgado H. Thorax. 2020 Mar;75(3):227-236. doi: 10.1136/thoraxjnl-2019-213571. Epub 2019 Dec 10.
4. PF-04620110, a Potent Antidiabetic Agent, Suppresses Fatty Acid-Induced NLRP3 Inflammasome Activation in Macrophages. Jo SI, Bae JH, Kim SJ, Lee JM, Jeong JH, Moon JS*. Diabetes Metab J. 2019 Oct;43(5):683-699. doi: 10.4093/dmj.2019.0112.
5. DROSHA-Dependent AIM2 Inflammasome Activation Contributes to Lung Inflammation during Idiopathic Pulmonary Fibrosis. Cho SJ, Hong KS, Jeong JH, Lee M, Choi AMK, Stout-Delgado HW, Moon JS*. Cells. 2019 Aug 20;8(8):938. doi: 10.3390/cells8080938.
6. Circulating Cell-Free mtDNA Contributes to AIM2 Inflammasome-Mediated Chronic Inflammation in Patients with Type 2 Diabetes. Bae JH, Jo SI, Kim SJ, Lee JM, Jeong JH, Kang JS, Cho NJ, Kim SS, Lee EY, Moon JS*. Cells. 2019 Apr 8;8(4):328. doi: 10.3390/cells8040328.
7. Upregulation of the NLRC4 inflammasome contributes to poor prognosis in glioma patients. Lim J, Kim MJ, Park Y, Ahn JW, Hwang SJ, Moon JS, Cho KG, Kwack K. Sci Rep. 2019 May 27;9(1):7895. doi: 10.1038/s41598-019-44261-9.
8. RIPK3 promotes kidney fibrosis via AKT-dependent ATP citrate lyase. Imamura M, Moon JS, Chung KP, Nakahira K, Muthukumar T, Shingarev R, Ryter SW, Choi AM, Choi ME. JCI Insight. 2018 Feb 8;3(3):e94979. doi: 10.1172/jci.insight.94979. eCollection 2018 Feb 8.
9. Moon JS1, Nakahira K, Chung KP, DeNicola GM, Koo MJ, Pabón MA, Rooney KT, Yoon JH, Ryter SW, Stout-Delgado H, Choi AM. NOX4-dependent fatty acid oxidation promotes NLRP3 inflammasome activation in macrophages. Nature Medicine. 2016 Sep;22 (9):1002-12.
10. Moon JS1, Hisata S, Park MA, DeNicola GM, Ryter SW, Nakahira K, Choi AM. mTORC1-Induced HK1-Dependent Glycolysis Regulates NLRP3 Inflammasome Activation. Cell Reports. 2015 Jul 7;12(1).
11. Moon JS1, Lee S, Park MA, Siempos II, Haslip M, Lee PJ, Yun M, Kim CK, Howrylak J, Ryter SW, Nakahira K, Choi AM. UCP2-induced fatty acid synthase promotes NLRP3 inflammasome activation during sepsis. The Journal of Clinical Investigation. 2015 Feb;125(2):665-80.
