Faculty
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Kwon, Hyog Young, Ph.D.
Professor
Hematopoietic stem cells (HSCs), Cancer Stem Cells (CSCs), Self-renewal, Regeneration, Fibrosis
Room 308, SIMS
+82-41-413-5021
hykwon@sch.ac.kr
My lab is focused on cancer and cancer-associated diseases. Currently, we have four projects, including cancer stem cell, liver fibrosis and cancer, muscle wasting, and therapeutics.
Project I is identifying key signaling pathways in cancer stem cells (CSCs). CSCs have the ability to propagate cells, and are considered to be the cause of cancer relapse and metastasis. One of the key characteristics of both stem cells and cancer stem cells is their ability to self-renew. Due to the shared characteristics, it has been proposed that signals that regulate self-renewal of stem cells may also regulate the uncontrolled propagation of cancer cells. Thus, we have been interested in elucidating novel signaling pathways that regulate self-renewal of stem cells and how these same pathways are dysregulated in cancer formation.
Project II is studying liver fibrosis and liver cancer. Liver fibrosis is caused by liver damages, such as alcohol and virus infection, etc. and could be progressed into liver cancer. We are identifying key mechanistic insights on this progression using hepatic stellate cells and patient-derived samples.
Projct III is focused on muscle wasting or muscle atrophy. Muscle atrophy, such as sarcopenia and cachexia, that results in a state of weakness and atrophy of body is associated with many conditions, including aging, cancer, diabetes, and metabolic syndrome. We are elucidating the mechanisms and key signaling pathways implicated in muscle wasting.
Projct IV aims to develop therapeutic approaches against on the diseases mentioned above. We are studying immunotherapies using NKT or antibody against cancer, and testing small molecules against muscle wasting that we identified recently.
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Principal Investigator
권혁영 (Hyog Young Kwon) B.S. in pharmacy, Sung Kyun Kwan University, Korea M.S. in pharmacy, Sung Kyun Kwan University, Korea Ph.D. in pharmacy, Sung Kyun Kwan University, Korea Postdoctoral fellow, Duke University, USA Postdoctoral fellow, University of California, USA Assistant Professor, Soonchunhyang Institute of Medi-bio Science(SIMS), Soonchunhyang University, Korea Associate Professor, Soonchunhyang Institute of Medi-bio Science(SIMS), Soonchunhyang University, Korea Professor, Soonchunhyang Institute of Medi-bio Science(SIMS), Soonchunhyang University, Korea Research Associate 김광석 (Kwang Seock Kim) Research associate since 2017 Studying on liver diseases, such as liver fibrosis and livercancer Graduate Students Ita Novita Sari Graduate student since 2015 Studying on cancer stem cells and hematopoietic stem cells Yoseph Toni Wijaya Graduate student since 2018 Studying on muscle wasting and therapeutics Tania Setiawan Graduate student since 2019 Studying on immunotherapy and leukemia |
1. Renal Aging and Associated Diseases: Common Mechanisms and Therapeutic Approaches. Pharmacological Reviews Muhammad JA, Julianto NM, Setiawan T, Wirawan LM, Jeong D, Kwon HY. 100148 June 19, 2026
2. Ginsenoside Rd attenuates renal aging and fibrosis through inhibition of angiotensin II type 1 receptor signaling. Phytomedicine Setiawan T, Julianto NM, Wijaya YT, Fadjaray TF, Wirawan LM, Muhammad JA, Muvva C, Park K, Kim SW, Lee EY, Lee J, Lee MR, Ou Y, Zhao X, Kwon HY. 2026 Jun 10;159:158415.
3. Regulation of metabolic adaptation and leukemia progression by MUSASHI2-DEPTOR-KIF11 axis. Leukemia Setiawan T, Muhammad JA, Marcellina N, Wirawan LM, Jun N, Sari IN, Oehler VG, Kim D, Kwon HY. 2025 Dec;39(12):2935-2945.
4. Cancer cachexia: molecular mechanisms and treatment strategies. J Hematol Oncol Setiawan T, Sari IN, Wijaya YT, Julianto NM, Muhammad JA, Lee H, Chae JH, Kwon HY. 2023 May 22;16(1):54.
5. Ginsenoside Rd ameliorates muscle wasting by suppressing the signal transducer and activator of transcription 3 pathway. Journal of Cachexia, Sarcopenia, and Muscle. Wijaya YT, Setiawan T, Sari IN, Park K, Lee CH, Cho KW, Lee YK, Lim JY, Yoon JK, Lee SH, Kwon HY. 2022 Dec;13(6):3149-3162.
6. AMD1 is required for the maintenance of leukemic stem cells and promotes chronic myeloid leukemic growth. Sari IN, Yang YG, Wijaya YT, Jun N, Lee S, Kim KS, Bajaj J, Oehler VG, Kim SH, Choi SY, Park SH, Kim DW, Reya T, Han J, Kwon HY. Oncogene; 2021 Jan; 40(3):603-617
7. Kwon HY, Bajaj J, Ito T, Blevins A, Konuma T, Weeks J, Lytle NK, Koechlein CS, Rizzieri D, Chuah C, Oehler VG, Sasik R, Hardiman G, Reya T. Tetraspanin3 is required for the development and propagation of Acute myelogenous leukemia. Cell Stem Cell, 2015 Aug 6;17(2):152-64.
8. Ito, T*., Kwon HY*, Zimdahl, B., Congdon, K. L., Blum, J., Lento, W. E., Zhao, C., Lagoo, A., Gerrard, G., Foroni, L., Goldman, J., Goh, H., Kim, S. H., Kim, D. W., Chuah, C., Oehler, V. G., Radich, J. P., Jordan, C.T., and Reya T. Regulation of myeloid leukaemia by the cell-fate determinant Musashi. Nature, 2010, 466, 765-8 (*, co-first author)
