Faculty
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Lee, Jongsoon, Ph.D.Professor, President of SIMS
Insulin Resistance, Type 2 Diabetes, Inflammation, Obesity, Immunity
Room 404, SIMS
+82-41-413-5032
Jongsoon.lee@sch.ac.kr
Lee lab has been studying the underlying molecular mechanisms for the development of obesity-induced insulin resistance, especially focusing on investigating how immune cells are regulated by obesity and how these then mediate the development of obesity-induced systemic insulin resistance. The current research projects of Lee lab are on 1) assessing the metabolic functions of adipose tissue macrophages, 2) determining the role of adipose tissue NK cells in the development of obesity-induced inflammation and insulin resistance, and 3) investigating the molecular mechanisms how adipose tissue inflammation regulates insulin resistance in the liver, muscle and β-cells.
In addition, since insulin resistance and Type 2 Diabetes are systemic diseases, we have hypothesized further that obesity also regulates systemic immune cells and that this controls local inflammation. Lee laboratory has been testing these hypotheses by studying how immune cells in circulation and local tissues are regulated by obesity and how this then mediates the development of obesity-induced insulin resistance in animal models as well as in human, and our accumulating experimental evidence encouragingly supports these hypotheses.
Therefore, we believe that our research not only shows how the fields of metabolism and immunology in insulin resistance and Type 2 Diabetes can interact, it also shows the reciprocal significance of the fields of basic and clinical science.
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Principal Investigator
Jongsoon Lee, Ph.D Professor, Vice-President of SIMS, Director of RLRC Tel: +82-41-413-5032 Fax: +82-41-413-5006 E-mail: jongsoon.lee@sch.ac.kr Biography Education and Training 1979-1983 BS, Department of Zoology, Seoul National University 1983-1985 BS/MS, Department of Zoology, Seoul National University 1988-1994 Ph.D., Department of Biochemistry, Boston University, School of Medicine, Boston, USA 1994-1995 Research Associate, Boston University, School of Medicine, Boston, USA 1995-1999 Research Fellow, Joslin Diabetes Center, Harvard Medical School, Boston, USA Position 1999-2006 Research Associate, Joslin Diabetes Center, Boston, USA 1999-2009 Instructor, Harvard Medical School, Boston, USA 2006-2019 Assistant Investigator, Joslin Diabetes Center, Boston, USA 2009-2019 Assistant Professor, Harvard Medical School, Boston, USA 2019- Professor, Soon Chun Hyang University 2019- Vice President, Soonchunhyang Institute of Medi-Bio Science (SIMS) 2019- Director, Metabolic Disease Tissue Homeostasis Research Center (RLRC) 2023- President, Soonchunhyang Institute of Medi-Bio Science (SIMS) Lab Manager
정지원 (Jiwon Jeong) Researcher/Lab manager E-mail: jeongjiwon@sch.ac.kr 2013-2017 BS, Department of Biological Science, Hoseo University, South Korea 2017-2019 MS, Department of Biochemistry, Hoseo University, South Korea 2019.05- Researcher, Soonchunhyang Institute of Medi-Bio Science (SIMS), South Korea Research Topic: The role of adipose tissue macrophages in the development of obesity-induced inflammation and insulin resistance. Post-doctoral Researcher
홍문주 (Moonju Hong) E-mail: moonju.hong@sch.ac.kr 2010-2015 BS, Department of Food Nutrition, Sungshin Women’s University, South Korea 2015-2021 Ph.D., Department of Food Biotechnology, UST, South Korea 2021.03- Post-doctoral Researcher, Soonchunhyang Institute of Medi-Bio Science (SIMS), South Korea Research Topic: Genetic regulation of obesity-induced inflammation and insulin resistance. Graduate Students
김지은 (Jieun Kim) MS/Ph.D. Student E-mail: jieun.kim@sch.ac.kr 2015-2019 BS, Department of Medical-Bio Technology, Soon Chun Hyang University 2019- MS/Ph.D. Student, Department of Integrated Biomedical Science, Soonchunhyang Institute of Medi-Bio Science (SIMS), Soon Chun Hyang University, South Korea Research Topic: The role of NK cells in the development of obesity-induced inflammation, insulin resistance and Type 2 Diabetes.
Gracia Nathalie MS Student E-mail: gracia.nathalie@sch.ac.kr 2015-2020 BS, Department of Food Technology, Atma Jaya Catholic University, Indonesia 2020.09- MS Student, Department of Integrated Biomedical Science, Soonchunhyang Institute of Medi-Bio Science (SIMS), Soon Chun Hyang University, South Korea Research Topic: The role of classical inflammation in obesity
강하늘 (Haneul Kang) MS Student E-mail: khaneul.0514@gmail.com 2018-2021 BS, Department of Medical-Bio Technology, Soon Chun Hyang University 2021- MS Student, Department of Integrated Biomedical Science, Soonchunhyang Institute of Medi-Bio Science (SIMS), Soon Chun Hyang University, South Korea Research Topic: The role of circadian rhythm in the development of obesity-induced insulin resistance Researcher
이다현 (Dahyeon Lee) E-mail: leedahyeon@sch.ac.kr 2016-2021 BS, Department of medical-biotechnology, Dongguk university 2022.09 - Researcher, Soonchunhyang Institute of Medi-bio Science (SIMS), South Korea Alumini
Emirrio Renaldie Hartland (M.S. 2022) M.S. thesis title: Transcriptional Regulation of Adipose Tissue by Obesity and Feeding Conditions. |
2. Bonamichi, B. and Lee,J. (2017) Unusual Suspects in the Development of Obesity-Induced Inflammation and Insulin Resistance: NK cells, iNKT cells, and ILCs. Diabetes Metab J. 41, 229-25
4. Lee, B.C. and Lee,J. (2014) Cellular and molecular players in
adipose tissue inflammation in the development of obesity-induced insulin resistance. Biochim Biophys Acta.
1842, 446-462
