연구자
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이윤경, 이학박사교수
Gut microbiota, Intestinal stem cell, Gut organoid, Mucosal immune system
순천향의생명연구원 본관동 405호
041-413-5031
yunklee@sch.ac.kr
우리는 태어나고 자라면서 삶에서 다양한 미생물과 함께 살아가게 됩니다. 많은 수의 이 공생하는 미생물 군집을 마이크로바이오타라고 하며, 우리의 건강이 마이크로바이오타에 의해 조절 된다는 많은 연구가 최근 활발하게 보고 되고 있습니다. 마이크로바이오타는 오랜 시간을 걸쳐 우리 건강에 중요한 역할을 하도록 진화되어 왔습니다. 우리 몸의 면역 시스템 역시 공생 미생물과 병원체를 구별하는 등의 공생을 위한 정교한 기전을 발달시키며 진화해 왔습니다. 대장과 소장의 장관 내는 마이크로바이오타, 다양한 영양분들, 숙주 세포 등을 포함한 복잡한 생태계를 이루고 있기 때문에 공생미생물과 숙주 세포의 상호작용이 어떻게 조절되는지에 대한 이해가 필요합니다.
우리 실험실은 기본적으로 마이크로바이오타가 면역 시스템을 조절하는 기전을 이해하고 그 기전을 다양한 면역 관련 질환들의 예방과 치료에 활용하려 합니다.
최근 진행되고 있는 연구 주제는 다음과 같습니다.
1. 장 염증 상황의 마이크로바이오타 활용 연구
2. 점막 면역계에서 장 줄기, 상피세포 역할 연구
3. 면역 관련 질환들에서의 마이크로바이오타 역할 연구
4. 식이 변화 조건에서의 장내미생물과 면역세포 기능 연구
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Principal Investigator
Yun Kyung Lee, Ph.D. Associate Professor Gut microbiota, Intestinal stem cell, Gut organoid, Mucosal immune system Office: Room 405, SIMS Phone: +82-41-413-5031 E-mail: yunklee@sch.ac.kr Post-Doctoral Scholar. California Institute of Technology Ph.D. University of Alabama at Birmingham M.S. Pohang University of Science and Technology B.S. Chonnam National University Postdoctoral Researcher Panida Sittipo, Ph.D. Ph.D. SIMS, Soonchunhyang University M.S. Chulabhorn Graduate Institute, Thailand B.S. Kasetsart University, Thailand
Graduate Students
Jaeyoon Choi B.S. School of Systems Biomedical Science,
Soongsil University
Eunike Tiffany B.S. Food Technology,
Atma Jaya Catholic University of Indonesia Undergraduate Student
Ara Oh Department of Pharmaceutical Engineering,
Soonchunhyang University
Chanyoung Lee Department of Pharmaceutical Engineering,
Soonchunhyang University |
Sittipo P, Pham HQ, Park CE, Kang G, Yong Z, Ji HJ, Jang A, Seo HS, Shin J, Lee YK* Irradiation-induced intestinal damage is recovered by the indigenous gut bacteria Lactobacillus acidophilus. Frontiers in Cellular and Infection Microbiology (2020 Aug 18) 10:415
Sittipo P, Shim JW, Lee YK* Microbial metabolites determine host health and the status of some diseases. International Journal of Molecular Sciences (2019 Oct 24) 20(21);5296
Lobionda S, Sittipo P, Kwon HY, Lee YK* The role of the gut microbiota in intestinal inflammation with respect to diet and extrinsic stressors. Microorganisms (2019 Aug 19) 7(8):271
Lee YK*, Mehrabian P, Boyajian S, Wu WL, Selicha J, Vonderfecht S, Mazmanian SK The protective role of Bacteroides fragilis in a murine model of colitis-associated colorectal cancer mSphere (2018 Nov 14) 3(6)
Sittipo P, Lobionda S, Choi K, Sari IN, Kwon HY,ﾠLee YK* Toll-like receptor 2-mediated suppression of colorectal cancer pathogenesis by polysaccharide A fromﾠBacteroides fragilis. Frontiers in Microbiology (2018 Jul 17) 9:1588
Sittipo P, Lobionda S, Lee YK*, Maynard CL. Intestinal microbiota and the immune system in metabolic diseases. Journal of Microbiology (2018 Mar) 56(3): 154-162
Lee YK*, Landuyt AE, Lobionda S, Sittipo P, Zhao Q, Maynard CL. TCR-independent functions of Th17 cells mediated by the synergistic actions of cytokines of the IL-12 and IL-1 families. PLoS One (2017 Oct 12) 12(10): 1-17
Cekanaviciute E, Yoo BB, Runia TF, Debelius JW, Singh S, Nelson CA, Kanner R, Bencosme Y,ﾠLee YK, Hauser SL, Crabtree-Hartman E, Katz Sand I, Gacias M, Zhu Y, Casaccia P, Cree BAC, Knight R,ﾠMazmanian SK, Baranzini SE. Gut bacteria from multiple sclerosis patients modulate human T cells and exacerbate symptoms in mouse models. Proc. Natl. Acad. Sci. USA (2017 Oct 3) 114 (40): 10713-10718 [PMID: 28893978]
Wang Y, Godec J, Ben-Aissa K, Cui K, Zhao K, Pucsek AB, Lee YK, Weaver CT, Yagi R, Lazarevic V. The tranion factors T-bet and Runx are required for the ontogeny of pathogenic interferon-γ-producing T helper 17 cells. Immunity (2014 Mar 20) 40(3):355-66.
Zindl CL, Lai JF, Lee YK, Maynard CL, Harbour SN, Ouyang W, Chaplin DD, Weaver CT. IL-22-producing neutrophils contribute to antimicrobial defense and restitution of colonic epithelial integrity during colitis. Proc. Natl. Acad. Sci. USA (2013 Jul 30) 110(31):12768-73
Lee YK, Menezes JS, Umesaki Y, Mazmanian SK Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis. Proc. Natl. Acad. Sci. USA (2011 Mar 15) 108 Suppl 1:4615-22.
Palmer MT, Lee YK, Maynard CL, Oliver JR, Bikle DD, Jetten AM, Weaver CT Lineage-specific effects of 1,25-dihydroxyvitamin D(3) on the development of effector CD4 T cells. J. Biol. Chem. (2011 Jan 14) 286(2): 997-1004.
Lee YK, Mazmanian SK Has the microbiota played a critical role in the evolution of the adaptive immune system? Science (2010 Dec 24) 330(6012): 1768-73
Mukasa R, Balasubramani A, Lee YK, Whitley SK, Weaver BT, Shibata Y, Crawford GE, Hatton RD, Weaver CT. Epigenetic instability of cytokine and tranion factor gene loci underlies plasticity of the T helper 17 cell lineage. Immunity (2010 May 28) 32(5): 616-27.
Lee YK, Mukasa R, Hatton RD, Weaver CT. Developmental Plasticity of Th17 and Treg cells. Current Opinion in Immunology (2009 Jun) 21:1-7.
Lee YK, Turner H, Maynard CL, Oliver JR, Chen D, Elson CO, Weaver CT. Late developmental plasticity in the T helper 17 lineage. Immunity (2009 Jan 16)30(1): 92-107.
