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Faculty

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Choon-sik Park image

Sujung Song

Ph.D.

Associate Professor

Cancer metabolism, Bone metastasis, Signaling pathway, Cancer stem cell, Genetic engineered mouse model

  • Biography

       2004-2008       Ph.D. in Biological Science, KAIST, Korea

       2008-2009       Postdoctoral fellow, KAIST, Korea

       2009-2014       Postdoctoral fellow, Harvard Medical School, USA 

       2014-2018       Assistant Professor, Soonchunhyang Institute of Medi-bio Science(SIMS), Soonchunhyang University, Korea
       2018-              Associate Professor, Soonchunhyang Institute of Medi-bio Science(SIMS), Soonchunhyang University, Korea

  • Research Interest

       1. To elucidate the functions and regulation of novel pathological factors of cancer and stem cell disease through; 
         (1) To identify novel therapeutic targets to attenuate the sequelae of cancer and stem cell disease through multidisciplinary
              approach employing novel genetically engineered mouse models (GEMM) of cancer- and stemness–regulatory factor and long
              non-coding RNAs and metabolism-integrated physiologic approaches.

         (2) Defining the roles of facotr in metabolic reprogramming of cancer cells.
         (3) Corroborating the implication of non-coding RNA-mediated regulation of epigenetics in stem cell biology using new technologies
              to analyze a single cell.

       2. To identify novel therapeutic targets to attenuate the sequelae of cancer and stem cell disease through multidisciplinary approach
          employing novel genetically engineered mouse models (GEMM) of cancer- and stemness–regulatory factor and long non-coding
          RNAs and metabolism-integrated physiologic approaches.​

  • Selected Publication

       1. Vila IK, Park MK, Setijono SR, Yao Y, Kim H, Badin PM, Choi S, Narkar V, Choi SW, Chung J, Moro C, Song MS*, Song SJ* . A
           muscle-specific UBE2O/AMPK α2 axis promotes insulin resistance and metabolic syndrome in obesity. (2019) JCI Insight. 11;4(13)    
      
    2 . Park MK, Yao Y, Xia W, Setijono SR, Kim JH, VilaIK, Chiu H, Wu Y, González Billalabeitia E, Lee MG, Kalb RG, Hung M, PandolfiPP,
           Song MS*, Song SJ* . PTEN self-regulates through USP11 via the PI3K-FOXO pathway to stabilize tumor suppression. (2019)
           Nature Communications. 7;10(1):636  

       3 . IK Vila, Y Yao, G Kim, W Xia, H Kim, SJ Kim,MK Park, JP Hwang, E González-Billalabeitia, MC Hung, SJ Song* , MS Song*. A
           UBE2O-AMPK
    α2 Axis that Promotes TumorInitiation and Progression Offers Opportunities for Therapy. (2017) Cancer Cell. 13;31
           (2):208-224  

       4. SJ Song, L Poliseno, MS Song, U Ala, KWebster, C Ng, G Beringer, NJ Brikbak, X Yuan, LC Cantley, AL Richardson, PPPandolfi.
           MicroRNA-Antagonism Regulates Breast Cancer Stemness and Metastasisvia TET-Family-Dependent Chromatin Remodeling.
           (2013) Cell. 154:311-24.  

       5. SJ Song*, K Ito*, U Ala, L Kats, KWebster, SM Sun, M Jongen-Lavrencic, K Manova-Todorova, J Teruya-Feldstein, DEAvigan, R
           Delwel, PP Pandolfi. The Oncogenic MicroRNA miR-22 Targets the TET2Tumor Suppressor to Promote Hematopoietic Stem Cell
           Self-Renewal and Transformation. (2013) Cell Stem Cell. 13:87-101.