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Faculty

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Choon-sik Park image

Jaeseok Han

Ph.D.

Associate Professor

Metabolic diseases, Endoplsamic resticulum stress, human diseases

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  • Biography

       B.S. in Molecular Biology, Seoul National University, Korea

       M.S. in Molecular Biology, Seoul University, Korea

       Ph.D. in Molecular Medicine, University of Calgary, Canada

       Postdoctoral fellow, Chicago Medical School, USA

       Postdoctoral fellow, University of Michigan, USA

       Staff Scientist, Sanford Burnham Medical Research Institute, USA

       Assistant Professor, Soonchunhyang Institute of Medi-bio Science(SIMS), Soonchunhyang University, Korea
       Associate Professor, Soonchunhyang Institute of Medi-bio Science(SIMS), Soonchunhyang University, Korea

  • Research Interest

       Metabolic diseases, Endoplsamic resticulum (ER) stress, human diseases, Metabolic inflammation, Diabetes

       1. Elucidation of cellular events upon ER stress in terms of unfolded protein response (UPR) during pathogenesis of metabolic diseases in
           the liver and pancreatic beta cells.

       2. Development of therapeutic target molecules to apply for ER stress-related human diseases including diabetes, fatty liver diseases etc.

       3. Elucidation of connection between ER stress and metabolic inflmmation especially during the pathogenesis of obesity-mediated insulin
           resistance

       4. Identification of potential role of microRNAs in UPR upon ER stress, especially when eIF2a is phosphorylated and protein synthesis is
           attenuated.

       5. Elucidation of possible correlation between ER stress and neurodegenerative diseases and stem cell differentiation.

  • Selected Publication

       1. Han J, Song B, Kim J, Kodali VK, Pottekat A, WangM, Hassler J, Wang S, Pennathur S, Back SH, Katze MG, Kaufman RJ. (2015) Antioxidants  
           complement the requirement for protein chaperone function tomaintain beta cell function and glucose homeostasis. Diabetes, 64(8):2892-2904

       2. Han J, KaufmanRJ (2014). Measurement of the Unfolded Protein Response (UPR) to investigateits role in adipogenesis and obesity.
           Methods Enzymol. 538C:135-150

       3. *Krokowski D, *Han J, Saikia M, Majumder M, Yuan CL,Guan BJ, Bevilacqua E, Bussolati O, Broer S, Arvan P, Tchorzewski M, Snider  
           MD, Puchowicz M, Croniger CM, Kimball SR, Pan T, Koromilas AE, Kaufman RJ, andHatzoglou M. (2013). A Self-Defeating Anabolic Program
           Leads to beta cellapoptosis in ER Stress-Induced Diabetes via Regulation of Amino Acid Flux. J Biol Chem 288(24):17202-13

       4. *Han J, *Back SH, Hur J, Lin YH, Gildersleeve R, ShanJ, Yuan CL, Krokowski D, Wang S, Hatzoglou M, Kilberg MS, Sartor MA, andKaufman RJ.
           (2013). ER-stress-induced transcriptional regulation increases proteinsynthesis leading to cell death. Nature cell biology 15(5):481-90

       5. Han J, Murthy R, Wood B, Song B, Wang S, Sun B, Malhi H, Kaufman RJ (2013) Phosphorylation of eukaryotic translation initiationfactor 2
           alpha induces CHOP to suppress adipocyte differentiation Diabetologia 56(4): 911-924