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Faculty

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Choon-sik Park image

Yongsung Hwang

Ph.D.

Associate Professor

Biomaterials, Stem Cell Engineering, 3D bioprinting, ECM remodeling, Mechanotransduction

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  • Biography

       B.S. in Materials Science and Engineering, Sungkyunkwan University, Korea

       M.S. in Materials Science and Engineering, UC San Diego, USA

       Ph.D. in Materials Science and Engineering, UC San Diego, USA

       Postdoctoral Researcher, Bioengineering, UC San Diego, USA

       Assistant Professor, Soonchunhyang Institute of Medi-bio Science(SIMS), Soonchunhyang University, Korea
       Associate Professor, Soonchunhyang Institute of Medi-bio Science(SIMS), Soonchunhyang University, Korea

  • Research Interest

      Biomaterials, Stem Cell Engineering, 3D bioprinting, ECM remodeling, Mechanotransduction

      Developing the next generation of regenerative medicine-based therapies requires a critical understanding encompassing
      biology, materials science, physiology, medicine, and engineering. Therefore, my research interest lies in:
     ​

      Aim1: Development of novel stem cell-based therapeutics for musculoskeletal tissue regeneration  – We try to
      (1) develop an efficient strategy to direct lineage-specific in vitro commitment of patent-specific induced pluripotent stem cells
      into various musculoskeletal tissues by integrating insoluble, matrix-based cues along with soluble cues, and (2) evaluate their
      tissue regeneration efficacy by biomimetic material-assisted in vivo transplantation.


       Aim2: Development and design of cutting-edge biomaterials for regenerative and tissue engineering applications
        We try to (1) design and fabricate novel hydrogel-based 3D scaffolds with biomimetic and hierarchical structures for stem cell
      fate commitment and novel co-culture system using 3D printing, electrospinning/spraying, microfabrication techniques, and (2)
      develop functional in vitro disease model platforms as an organ-on-a-chip model.

  • Selected Publication

       1. H. Kabra#, Y. Hwang#, M. Kar, and S. Varghese. Biomimetic material-assisted delivery of stem cells enhances in vivo
          
    engraftment. (2015) ACS Biomaterials Science and Engineering, 1, 7-12. (# denotes co-first author)

       2. M. Nakasaki, Y. Hwang, Y. Xie, S. Kataria, R. Gund, E. Y. Hajam, R. Samuel, R. George, D. Danda, P. MJ, T. Nakamura, Z.
           Shen, S. Briggs, S. Varghese, and C. Jamora. The matrix protein Fibulin-5 lies at the interface of tissue stiffness and
           inflammation in fibrosis. (2015) Nature Communications, 6:8574.

       3. Y. Hwang, S. Suk, T. Seo, B. Du, Y. Xie, Z. Li, and S. Varghese. WNT3A promotes myogenesis of human embryonic stem cells
           and enhances in vivo engraftment. (2014) Scientific Reports, 4, 5916; DOI: 10.1038/srep05916.

       4. Y-R. V. Shih, Y. Hwang, A. Phadke, H. Kang, N. Hwang, E. Caro, S. Nguyen, M. Siu, E. Theodorakis, N. Gianneschi, K. Vecchio,
          S. Chien, O. Lee, and S. Varghese. Calcium phosphate-bearing matrices induce osteogenic differentiation of stem cells through
          adenosine signaling. (2014) PNAS, 111(3): 990-5.

       5. C. Chang#, Y. Hwang#, D. Brafman, T. Hagan, C. Phung, and S. Varghese. Engineering cell-material interfaces for long-term
          expansion of human pluripotent stem cells. (2013) Biomaterials, 34(4), 912-21. (# denotes co-first author)