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Faculty

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Choon-sik Park image

Hyog Young Kwon

Ph.D.

Associate Professor

Hematopoietic stem cells (HSCs), Cancer Stem Cells (CSCs), Self-renewal, Regeneration, Fibrosis

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  • Biography

       B.S. in pharmacy, Sung Kyun Kwan University, Korea

       M.S. in pharmacy, Sung Kyun Kwan University, Korea

       Ph.D. in pharmacy, Sung Kyun Kwan University, Korea

       Postdoctoral fellow, Duke University, USA

       Postdoctoral fellow, University of California, USA

       Assistant Professor, Soonchunhyang Institute of Medi-bio Science(SIMS), Soonchunhyang University, Korea
       Associate Professor, Soonchunhyang Institute of Medi-bio Science(SIMS), Soonchunhyang University, Korea 

  • Research Interest

       One of the key characteristics of both stem cells and cancer stem cells is their ability to self-renew. Due to the shared characteristics,
       it has been proposed that signals that regulate self-renewal of stem cells may also regulate the uncontrolled propagation of cancer cells.
       Thus, we have been interested in elucidating novel signaling pathways that regulate self-renewal of stem cells and how these same
       pathways are dysregulated in cancer formation. Specifically, we have been trying to identify distinct pro-renewal or differentiation
       signals in both stem cells and cancer stem cells and to inhibit these signaling pathways effectively to prevent the propagation of cancer
       cells. We use animal models such as knockout mice and transgenic mice to investigate the characteristics of self-renewal in several
       systems including hematopoietic stem cells, colon cancer, lung cancer, etc.

  • Selected Publication

       1. Yang Y, Koh YW, Sari IN, Jun N, Lee S, Phi LTH, Kim KS, Wijaya YT, Lee SH, Baek MJ, Jeong D, Kwon HY, Interferon-induced
          transmembrane protein 1-mediated EGFR/SOX2 signaling axis is essential for progression of non-small cell lung cancer.
    Int J
          Cancer
    . 2019 Apr 15;144(8):2020-2032. doi: 10.1002/ijc.31926. Epub 2018 Dec 8.
       2. Kim KS, Jeong D, Sari IN, Wijaya YT, Jun N, Lee S, Yang YG, Lee SH, Kwon HY. miR551b Regulates Colorectal Cancer
          Progression by Targeting the ZEB1 Signaling Axis.
    Cancers (Basel). 2019 May 27;11(5). pii: E735. doi: 10.3390/cancers11050735.
          PMID: 31137914 
       3. Sari IN, Phi LTH, Jun N, Wijaya YT, Lee S, Kwon HY. Hedgehog Signaling in Cancer: A Prospective Therapeutic Target for
          Eradicating Cancer Stem Cells.
    Cells. 2018 Nov 10;7(11). pii: E208. doi: 10.3390/cells7110208.
       4. Kwon HY, Bajaj J, Ito T, Blevins A, Konuma T, Weeks J, Lytle NK, Koechlein CS, Rizzieri D, Chuah C, Oehler VG, Sasik R,
          Hardiman G, Reya T. Tetraspanin3 is required for the development and propagation of Acute myelogenous leukemia.
    Cell Stem
          Cell
    , 2 2015 Aug 6;17(2):152-64. doi: 10.1016/j.stem.2015.06.006. Epub 2015 Jul 23. 
       5. Ito, T., Kwon HY, Zimdahl, B., Congdon, K. L., Blum, J., Lento, W. E., Zhao, C., Lagoo, A., Gerrard, G., Foroni, L., Goldman, J.,
          Goh, H., Kim, S. H., Kim, D. W., Chuah, C., Oehler, V. G., Radich, J. P., Jordan, C.T., and Reya T. Regulation of myeloid leukaemia
          by the cell-fate determinant Musashi.
    Nature, 2010, 466, 765-8.