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Faculty

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Choon-sik Park image

Man Ryul Lee

Ph.D.

Associate Professor

Pluripotent stem cell, developmental biology, microRNA, metabolism

  • Biography

       B.S. in Animal Bioscience and Technology, KonKuk University, Korea

       M.S. in Biomedical Sciences & Engineering, Korea University, Korea

       Ph.D. in Biomedical Sciences, Hanyang University, Korea

       Postdoctoral fellow, Indiana Univeristy, USA

       Assistant Professor, Soonchunhyang Institute of Medi-bio Science(SIMS), Soonchunhyang University, Korea
       Associate Professor, Soonchunhyang Institute of Medi-bio Science(SIMS), Soonchunhyang University, Korea 

     

  • Research Interest

       Pluripotent stem cell, developmental biology, microRNA, metabolism 

       1. The study of microRNA-mediated pluripotency and reprogramming.

       2. The study of cellular organelles in maintaining stem cell niche.

       3. The understanding of endothelial development and differentiation mechanisms and application of the data to regenerative medicine.

     

  • Selected Publication

       1. Heung-Mo Yang, Jong-Jin Choi, Ha-Na Kim, Seung Jip Yang, Soon-Jung Park, Changhee Kang, Hyung-Min Chung, Man Ryul Lee,
           Sung Joo Kim, Sung-Hwan Moon. (2019) Reconstituting human cutaneous regeneration in humanized mice under endothelial cell
           therapy.
    Journal of Investigative Dermatology 139(3) 697-701
       2. Bin Guo, Xinxin Huang, Man Ryul Lee, Sang A Lee & Hal E Broxmeyer (2018) Antagonism of PPAR-γ signaling expands human
           hematopoietic stem and progenitor cells by enhancing glycolysis.
    Nature Medicine, Mar; 23(3):360-367
       3. Soon-Jung Park, Sang A Lee, Nutan Prasain, Daekyeong Bae, Hyunsu Kang, Taewon Ha, Jong Soo Kim, Ki-Sung Hong, Charlie
           Mantel, Sung-Hwan Moon, Hal E. Broxmeyer, and
    Man Ryul Lee (2017) Metabolome profiling of partial and fully reprogrammed
           iPSCs.
    Stem Cells and Development, 26, (10) 734-742
       4. Man Ryul Lee, Charlie Mantel, Sang A Lee, Sung-Hwan Moon and Hal E. Broxmeyer. (2016) MiR-31/SDHA axis Regulates
           Reprogramming Efficiency through Mirtochondrial Metabolism.
    Stem Cell Reports, 2(7) 1-10
       5. Nutan Prasain, Man Ryul Lee, Sasidhar Vemula, Jonathan Luke Meador, Momoko Yoshimoto, Michael J. Ferkowicz, Alexa Fett1,
           Manav Gupta, Brian M. Rapp, Mohammad Reza Saadatzadeh, Michael Ginsberg, Olivier Elemento, Younghee Lee, Sherry L. Voytik-
           Harbin, Hyung Min Chung, Ki Sung Hong, Emma Reid, Christina L. O’Neill, Medina J. Reinhold, Alan W. Stitt, Michael P. Murphy,
           Shahin Rafii, Hal E. Broxmeyer, and Mervin C. Yoder. (2014) Differentiation of human pluripotent stem cells to cells similar to cord-
           blood endothelial colony
    forming cells. Nature Biotechnology Vol.32,(11)1151-1157