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Faculty

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Choon-sik Park image

Jae-won Shim

Ph.D.

Associate Professor

Human Pluripotent Stem Cells, Stem Cell Differentiation

  • Biography

       B.S. in Chemical Engineering, Seoul National University, Korea

       M.S. in Biological Engineering, Seoul National Universit,, Korea

       Ph.D. in Biological Engineering, Seoul National University, Korea

       Postdoctoral Fellow, Hanyang University, Korea

       Postdoctoral Fellow, Sloan Kettering Institute, New York, USA

       Assistant Professor, Soonchunhyang Institute of Medi-bio Science(SIMS), Soonchunhyang University, Korea
       Associate Professor, Soonchunhyang Institute of Medi-bio Science(SIMS), Soonchunhyang University, Korea 

  • Research Interest

       Human Pluripotent Stem Cells, Stem Cell Differentiation; Neuronal differentiation, Midbrain Donpamine neurons; 
       Parkinson’s disease

       My research is focused on derivation of functional midbrain dopamine neurons from various cell sources including human Pluripotent 
       Stem Cells. One main application is the development of a cell replacement therapy for Parkinson’s disease using human ES or iPS cell 
       derived dopamine neurons. The second main research direction is the use of normal and Parkinson’s disease-specific pluripotent stem 
       cell lines to study the function of genes involved in human brain development and in the pathology of Parkinson’s disease

  • Selected Publication

       1. Kriks S*, Shim JW*, Piao J, Ganat YM, Wakeman DR, Xie Z, Carrillo-Reid L, Auyeung G, Antonacci C, Buch A, Yang L, Beal
       MF,Surmeier DJ, Kordower JH, Tabar V, Studer L. (2011) Dopamine neurons derived from human ES cells efficiently engraft in
       animal models of Parkinson's disease.
    Nature 480:547-551. * equally contributed

       2. Chung SY, Kishinevsky S, Mazzulli JR, Graziotto J, Mrejeru A, Mosharov EV, Puspita L, Valiulahi P, Sulzer D, Milner TA, Taldone T,
       Krainc D, Studer L,
    ShimJW (2016) Parkin and PINK1 patienti PSC-derived midbrain dopamine neurons exhibit mitochondrial
       dysfunction and
    α-synuclein accumulation. Stem Cell Reports 7(4):664-677.

       3. Puspita L, Chung SY, ShimJW (2017) Oxidative stress and cellular pathologies in Parkinson’s disease. Molecular Brain 10:53.

       4. Rhee YH, Puspita L, Sulistio YA, Kim SW, Vidyawan V, Elvira R, Chang MY, Shim JW*, Lee SH* (2019) Efficient Neural
       Differentiation of hPSCs by Extrinsic Signals Derived from Co-cultured Neural Stem or Precursor Cells.
    Molecular Therapy 27
       (7):1299-1312. * co-corresponding

       5. Riessland M, Kolisnyk B, Kim TW, Cheng J, Ni J, Pearson JA, Park EJ, Dam K, Acehan D, Ramos-Espiritu LS, Wang W, Zhang J,
       Shim JW
    , Ciceri G, Brichta L, Studer L, Greengard P (2019) Loss of SATB1 Induces p21-Dependent Cellular Senescence in Post-
       mitotic Dopaminergic Neurons.
    Cell Stem Cell 25(4):514-530