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[Seminar Notification] Dr. Yong-Mahn Han_04.27.2016
2016-04-20

1. Title : Epigenetic dynamics in human pluripotent stem cells

2. Speaker : Yong-Mahn Han, Ph.D.

3. Affiliation : Professor, Department of Biological Sciences, KAIST

4. Date : 04. 27. 2016 16:00-17:00

5. Place : SIMS Main Building, Auditorium 109 (1F)

6. Abstract

Pluripotent stem cells (PSCs) can be derived from preimplantation embryos, cloned embryos, and somatic cells via cellular reprogramming. PSCs such as embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) retain the unique epigenetic state to maintain their self-renewal and pluripotency. Differentiation of PSCs into a specialized cell type entails remarkable changes of epigenetic states to activate expression of cell type-specific genes. However, dynamics of epigenetic marks are poorly understood in PSCs during differentiation into specialized cell types. In this context, we have been studied temporal expression and epigenetic status of lineage-specific genes in human PSCs during differentiation in vitro. As results, variations in the dynamics of epigenetic modifications associated with expression of lineage-specific genes were observed in human ESCs during differentiation into hepatocytes. Transcriptional and epigenetic variations in lineage-specific genes were detected among human PSC lines. Allelic expression of imprinted genes was relatively stable in human PSCs during in vitro differentiation. Recently, we found that methylated LIN28A blocks the process of pri-let-7 microRNA by multimeric binding to maintain the self-renewal of human ESCs. Our findings provide in vitro model for epigenetic dynamics related to self-renewal and differentiation of human PSCs.